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The incretin effect is very brief because it remains active 12 min after its secretion and is then inactivated by the enzyme dipeptidylpeptidase-4 (DPP-4) [7]

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Several factors influence whether this combined approach might be suitable, including the type of hormone therapy, your baseline health, and how your body responds to each treatment

13 Less common but important side effects include: Gallstones (rare) Kidney problems, especially in older adults who already have kidney disease Significant weight loss, which could be concerning for frail elderly people Special considerations for older adults: Stomach problems can lead to dehydration, which can be more serious in older adults